The Binding of Isaac: Repentance Tainted Characters Guide (2024)

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It can be extremely difficult to keep track of new additions toThe Binding of Isaac when updates are added, and that’s especially true of large DLCs like Repentance. We’re currently playing our way throughthe newest (and supposedly final) additionforThe Binding of Isaac, and one element that could use some explaining is the inclusion ofTainted Characters.

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Every playable character inThe Binding of Isaac: Repentance has a “tainted” version. Even though they look like reskins of Cain, Isaac, Lilith, and the rest, most of them start with new items and abilities, effectively doubling the way you can begin a new run once they’re unlocked. Here’s how to unlock each tainted character and what makes them special.

How to Unlock Tainted Characters

Unlocking tainted characters is simple to explain, as the process is the same for each one. However, it is time consuming if you want to catch ’em all, and you need to string together a good run in order to reach the point where you can access them. Here’s how you do it.

Defeat Mother

You’ll need to defeatMother at least once. This is a new boss added to theRepentance DLC, and you’ll find her at the end of theCorpse II biome.

Find Dad’s Note

You’ll need to findDad’s Note on another run. This is a special item you’ll be able to grab in the biomeDepths II. To find it, you’ll need to defeat the boss and then teleport out of the room. Look for a slightly different skull somewhere in the level and bomb it in order to find aFool card if you don’t have teleportation.

Return to the starting room after defeating the boss, and you’ll find a door that can be opened withThe Polaroid,The Negative or theFaded Polaroid. You’ll find Dad’s Note inside this room and you’ll begin your ascension.

Reach Home

Go all the way through the Ascension and you’ll reach a new area calledHome. It isn’t randomized like the other areas ofTheBinding of Isaac,so work your way through the few rooms and you’ll get toMom’s Room. Open the chest here to find theRed Key item, unlocking it for future runs. You can now use this item to unlockTainted Characters.

Use the Red Key

Go into the hall outside of Mom’s Room and use the Red Key. It will open a hidden room with the tainted version of the character you are playing as inside. Touch that character to unlock them for future runs.

Find the Cracked Key

Unfortunately, you won’t continue to find the Red Key in Mom’s Room in later runs. You’ll either need to carry it to the area or find theCracked Key item, which is a consumable that has the same effect as the Red Key.

A good tip for finding theCracked Key is to drop any trinket item inside a boss room after you’ve defeated your enemy. When you are going through the Ascent after finding Dad’s Note, you’ll take a trip through each boss room you previously visited, but any trinket you’ve left behind will be transformed into the Cracked Key.

It’s certainly a process but, like many things inThe Binding of Isaac, you’ll find a rhythm as you start working your way through. Take each character through the Ascent to the Home area and use the Red/Cracked Key in the room before Mom’s Room to get all the tainted characters.

Tainted Character Traits

Most of the tainted characters have similar traits to their regular counterparts, but they generally all have an extremely powerful ability balanced by a significant drawback.

They all have varying levels of starting stats and the like, but here are the main things that separate each tainted character from their regular versions.

  • Tainted Isaac:Every item pedestal cycles between two options, but you can only hold eight passive items at a time.
  • Tainted Magdalene:Has a powerful melee attack that triggers when an enemy touches her and leaves a trail behind her that damages enemies, but her health slowly drains down to two red hearts.
  • Tainted Cain:Starts with theBag of Crafting item, which stores pickups and transforms them into a passive item when used. However, Tainted Cain can only obtain items through this method.
  • Tainted Judas:Starts with theDark Arts active item instead of theBook of Belial. This active item gives him an invulnerable charge attack.
  • Tainted ???:Starts with theHold active item and nearly every pickup is replaced by poop variations. Hold allows Tainted ??? to store his leftmost poop (he can hold up to nine) for later use.
  • Tainted Eve:Starts with theSumptoriumactive item instead of Eve’s regular items. When active, it drains Eve’s health to summon Blood Clot familiars while she is shooting tears.
  • Tainted Samson:Has a similarBerserk effect to regular Samson, but it restricts him to a powerful melee weapon and also has a timer that refills as he kills enemies.

  • Tainted Azazel:Has a fullscreen beam attack that does low damage, and also has a high knockback, close range attack that leaves enemies vulnerable to his beam. Tainted Azazel cannot fly.
  • Tainted Lazarus:Swaps between his living and dead form after each room. Each form has different stats and abilities, making this a tricky character to master.
  • Tainted Eden:Starts with random stats and items, and they are all rerolled each time Tainted Eden takes damage.
  • Tainted Lost:Starts with theHoly Card consumable, which will shield you from a single damage source. The drop rate for Holy Cards is much higher when you play as Tainted Lost.
  • Tainted Lilith:Starts with theC Section passive item, which replaces Tainted Lilith’s tears attack with a baby attached by an umbilical cord (!!!!). The babe deals damage and can also fire tears at enemies.
  • Tainted Keeper:Every item is acquired by coins, and Tainted Keeper also uses coins for health. Defeating enemies drops temporary coins that quickly vanish if they aren’t picked up.
  • Tainted Apollyon:Begins with theAbyss item, which sucks in every item in the room and spawns an attack fly familiar for each item that you can fire at enemies.
  • Tainted Forgotten:Has a skeleton familiar that you can throw at foes, dealing heavy damage. Cannot obtain red hearts.
  • Tainted Bethany:Begins with theLemegeton active item, which grants a random passive item. Tainted Bethany cannot obtain red heart health, instead using red hearts to power her active item usage if it isn’t fully charged.
  • Tainted Jacob:Begins with theAnima Sola item, which restricts actions from the closest enemy for five seconds. You’ll need it, as Tainted Jacob will start being chased down 30 seconds into each floor byDark Esau. If Dark Esau catches Tainted Jacob, he transforms into a character similar to The Lost, and one more hit will kill him. If you make it to the next floor as this ghostly figure, Tainted Jacob will be returned to his “living” state.

All these tainted characters add unique spins on the game, and a few of them will dramatically change the way you have to playThe Binding of Isaac in order to succeed. Good luck surviving the basem*nt, and check out our game page for more on The Binding of Isaac: Repentance!

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The Binding of Isaac: Repentance Tainted Characters Guide (2024)

FAQs

How to unlock tainted characters fast? ›

  1. Drop a trinket on a item/boss room.
  2. Beat Mon in Dephts 2 and teleport out to place the Polaroid/Negative on the Strange Door.
  3. When ascending the basem*nt look for the room in which you dropped your trinket and it will have transformed into a Cracked Key.

How to get red key for tainted characters? ›

Notes
  1. The Red Key is guaranteed the first time Isaac enters. ...
  2. In order to guarantee an unlock on subsequent trips to Home, Isaac must leave a trinket in either a Treasure Room or a Boss Room. ...
  3. To unlock these characters, Isaac does not need to defeat Dogma or The Beast on the run he opens the closet.

Does Rock Bottom work with tainted Isaac? ›

Rock Bottom: Prevents any stat from decreasing, letting the effects of picked up items linger even after discarding them. However, raising stats beyond the values reached will be more difficult after leaving the source item, and swapping away Rock Bottom resets them to Tainted Isaac's current set.

What is the easiest character to unlock in the binding of Isaac? ›

Lazarus stands as one of the easiest characters to unlock, although it may take a bit of doing. Players need to have 4 Soul Hearts or Black Hearts at once. Soul Hearts aren't that hard to come by, but players will need to be careful about how much damage they take, as Soul Hearts are always lost first.

What does tainted Lazarus do? ›

Upon defeating the boss, Tainted Lazarus will Flip automatically, allowing the duplication of Devil or Angel Items, followed by flipping and taking the same item on the other form.

How rare is the Red Key? ›

The Red Key is a guaranteed (100%) drop from the Dough King if the player did 10% damage or more.

What does tainted azazel do? ›

Technology: Makes his "thin brimstone" have electricity coiled around it and applies a x1.5 damage multiplier.

What does tainted Bethany do? ›

Red Key: With her blood charges, Tainted Bethany can explore more red rooms than other characters, allowing her to gain the benefits of red special rooms easily. In turn, this allows her to use Lemegeton to gain items from those item pools in addition to their normal contents.

How to unlock Apollyon? ›

To unlock Apollyon, you must defeat Mega Satan in the Dark Room while playing in the Afterbirth+ DLC. This requires you to first defeat Mom's Heart, then bomb the devil statue room to access the Negative pathway. Complete the Dark Room and defeat Mega Satan to unlock Apollyon.

How do you unlock Mr Resetter in Isaac? ›

The Binding of Isaac: Rebirth. So, the Mr. Resetter achievement, which is unlocked by resetting 7 times consecutively, unlocks the Sticky Nickel of AB+, the half soul heart.

How do I get rid of tainted Esau? ›

Although difficult to accomplish, successfully dealing the final blow to Dark Esau with the Eraser will remove him for the rest of the run.

Do you lose transformations with tainted Isaac? ›

Tainted Isaac will not lose a transformation nor progress towards it if he replaces an item that counts towards that transformation.

How to unlock polyphemus? ›

It's all randomly generated, but the item itself is unlocked from the start, if that's what your asking. It will always be in the item pool, I'm pretty sure. Just play a bunch.

What does Tainted Judas do? ›

When you use tainted judas' ability, you become invincible for a duration. For the duration, you can walk through enemies and tears. At the end of the duration, you will teleport through all the enemies and tears you walked through, deal damage to them and get a temporary damage up from each one; the more the better.

How to get the Cracked Key in Isaac? ›

Cracked Key, which can be obtained through room drops or by leaving a trinket in a boss or item room and coming back to that room during the Ascent, and using it in the same spot.

How to unlock alternate characters in Isaac? ›

Opening the treasure chest for the first time will always reward you with a Red Key. Picking this up will unlock the Red Key for use in other runs, picked up as other useful items would be. This item is the key to unlocking Tainted characters.

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